If the results of the tests carried out suggest a diagnosis of prostate cancer, your doctor will refer you to a urologist.
Your urologist may repeat some of the tests that your GP has already carried out. To check whether you do have cancer, they will also perform a biopsy. Approximately two out of three men who have a biopsy will not have prostate cancer.
An ultrasound probe is inserted into the rectum, which guides an automated needle to the prostate. You may be given a local anaesthetic to reduce any discomfort during the biopsy. You may feel a sharp needle prick as 8-12 tiny samples of prostate tissue are taken. These samples are sent to a laboratory for examination under a microscope. You will usually be given antibiotics before and after the procedure and told to continue taking the prescribed antibiotic for several days afterwards.
For several weeks after the biopsy, you may notice blood in your urine, semen and/or bowel motions. Urinary infections can sometimes occur after a biopsy. You should contact your doctor if you feel unwell, have shaking attacks and/or a fever, or are having problems urinating.
Biopsy samples are small, so it is possible to miss small cancers. Your doctor may want to monitor your PSA level even if you receive a negative biopsy result. If your PSA level continues to rise, your doctor may request another biopsy.